Two RC F GT3s, campaigned by European teams Farnbacher Racing and Emil Frey Racing, finished first and second in the SPX prototype class and 10th and 11th in the overall classification.
Both cars also completed 28 laps of the full Nurburgring endurance racing circuit - the same as the overall winner - in a further confirmation of their pace and consistency.
The result marks a significant milestone for the program to hone the new Lexus RC F GT3 throughout 2015.
Farnbacher Racing and Emil Frey Racing are co-developing the RC F GT3 and will run the vehicle at other events of the VLN, a series of endurance races at the Nurburgring organised by German motoring clubs.
Japan's LM Corsa team is also running an RC F GT3 in the GT 300 class of the 2015 Japanese Super GT championship.
The Lexus RC F GT3 is built to comply with GT3 regulations, which are for grand tourer style racecars that can be campaigned in various championships around the world.
It is based on the Lexus RC F sports coupe but is lower, wider and weighs just 1250kg.
It also features a modified version of the RC F's 5.0-litre V8 engine that produces in excess of 400kW of power (540 horsepower).